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ativan vs valium dosage Whenever a new influenza virus emerges the ensuing outbreak can represent a crisis???with rapidly spreading illness and death that spreads from country to country. The 1918 Spanish influenza pandemic, for example, killed approximately 2 percent of the world population at the time or a staggering 50 million. Although the H1N1 flu did not come close to causing that high casualty rate, understanding the global impact of such a pandemic remains vitally important in order to plan and prepare for the next time a pandemic virus emerges, Simonsen says.